Objective: The objective of this study was to analyse publications related to examination techniques that might improve the visualisation of suspicious lesions of the oral mucosa (ViziLite® system and VELscope® system) or that might facilitate the cytological identification of suspicious lesions (OralCDx®). Methods: A literature search was performed, using the PubMed database and the key […]

The detection of oral cancer at an early stage is the most effective means to improve survival and reduce morbidity, disfigurement, duration of treatment, and hospital costs associated with this disease. However, approximately 30% of patients delay seeking help for more than 3 months following the self-discovery of symptoms of oral cancer. This study aimed […]

A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed. Patients in the Oral Dysplasia Clinics at British Columbiaare currently being examined with a simple hand-helddevice that permits the […]

Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions. Blue excitation light
400 to 460 nm is employed to excite green-red fluorescence from fluorophores […]

Conventional visual examination and palpation remains the gold-standard for the identification of oral mucosal lesions. The purpose of this study was to investigate the adjunctive value of a chemiluminescent light source (ViziLite, Zila Pharmaceuticals, Phoenix, Arizona) and application of pharmaceutical grade toluidine blue (TBlue630, Zila Pharmaceuticals, Phoenix, Arizona) to further assess lesions identified during the […]

La fluorescenza è una proprietà tipica di alcune molecole, chiamate fluorofori, in grado  di assorbire luce e riemetterla a una lunghezza d’onda maggiore. Nella pratica clinica,  i fluorofori esogeni sono sostanze fluorescenti somministrate dall’esterno che si accumulano  in specifici tessuti o si legano a specifici bersagli biologici, mentre i fluorofori  endogeni sono sostanze fluorescenti normalmente […]

Il corretto inquadramento diagnostico e terapeutico è condizione indispensabile per garantire risultati ottimali in qualunque patologia neoplastica. La classificazione TNM, nata oltre cinquant’anni fa, è la più efficace proposta di un linguaggio comune per lo scambio di informazioni prognostiche e risultati oncologici e per la programmazione terapeutica. Dal Gennaio 2003 è entrata in vigore la […]