Various specialty clinics and research centers have conducted studies of direct tissue fluorescence visualization as a screening technique for oral premalignant lesions and early oral squamous cell carcinoma (OSCC). The effectiveness of the VELscope in a private practice setting is unknown. This pilot study is the first report to assess the VELscope system as a […]
Fluorescence Visualization Detection of Field Alterations in TumorMargins of Oral Cancer Patients
Genetically altered cells could become widespread across the epithelium of patients with oral cancer, often in clinically and histologically normal tissue, and contribute to recurrent disease. Molecular approaches have begun to yieldinformation on cancer/risk fields; tissue optics could further extend our understanding of alteration to phenotype as a result ofmolecular change. Autori Catherine F. Poh […]
Adjunctive Techniques for Oral Cancer examination and lesion diagnosis
In the past decades, adjunctive techniques have emerged with claims of enhancing oral mucosal examinations and facilitating the detection of and distinctions between oral benign and oral premalignant and malignant lesions (OPML). Clinicians who use these tools may be unaware of the state of the evidence supporting their effectiveness. Techniques that are promoted or assessed […]
Analysis of new diagnostic methods in suspicious lesions of the oral mucosa
Objective: The objective of this study was to analyse publications related to examination techniques that might improve the visualisation of suspicious lesions of the oral mucosa (ViziLite® system and VELscope® system) or that might facilitate the cytological identification of suspicious lesions (OralCDx®). Methods: A literature search was performed, using the PubMed database and the key […]
Patient delay for potentially malignant oral symptoms
The detection of oral cancer at an early stage is the most effective means to improve survival and reduce morbidity, disfigurement, duration of treatment, and hospital costs associated with this disease. However, approximately 30% of patients delay seeking help for more than 3 months following the self-discovery of symptoms of oral cancer. This study aimed […]
Direct Fluorescence visualization
A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed. Patients in the Oral Dysplasia Clinics at British Columbiaare currently being examined with a simple hand-helddevice that permits the […]
Direct visualization of oral-cavity tissue fluorescence.
Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions. Blue excitation light 400 to 460 nm is employed to excite green-red fluorescence from fluorophores […]
Analysis of oral lesion biopsies
Conventional visual examination and palpation remains the gold-standard for the identification of oral mucosal lesions. The purpose of this study was to investigate the adjunctive value of a chemiluminescent light source (ViziLite, Zila Pharmaceuticals, Phoenix, Arizona) and application of pharmaceutical grade toluidine blue (TBlue630, Zila Pharmaceuticals, Phoenix, Arizona) to further assess lesions identified during the […]
Autofluorescenza dei tessuti molli del cavo orale
La fluorescenza è una proprietà tipica di alcune molecole, chiamate fluorofori, in grado di assorbire luce e riemetterla a una lunghezza d’onda maggiore. Nella pratica clinica, i fluorofori esogeni sono sostanze fluorescenti somministrate dall’esterno che si accumulano in specifici tessuti o si legano a specifici bersagli biologici, mentre i fluorofori endogeni sono sostanze fluorescenti normalmente […]
Percorsi diagnostici e terapeutici. Neoplasie di cavo orale, faringe, laringe, ghiandole salivari, tiroide
Il corretto inquadramento diagnostico e terapeutico è condizione indispensabile per garantire risultati ottimali in qualunque patologia neoplastica. La classificazione TNM, nata oltre cinquant’anni fa, è la più efficace proposta di un linguaggio comune per lo scambio di informazioni prognostiche e risultati oncologici e per la programmazione terapeutica. Dal Gennaio 2003 è entrata in vigore la […]