of calcium and magnesium 7-14
of hormones 7-13, 7-14
Biologic variability
age-based variability
biorhythms
circadian rhythms 6-8
menstrual cycle 6-9
components of 1-5, 6-1
continuous heterogeneity
definition 6-1
constructing a reference frequency distribution 6-3
definition 1-5
discrete heterogeneity
definition 6-1
constructing a reference frequency distribution 6-1
race-based variability
constructing reference frequency distributions 6-6
geographic races of man 6-5
sex-based variability
causes 6-4
pregnancy 6-5
sources of 1-5, 6-1
Biorhythms
circadian rhythms 6-8
menstrual cycle 6-9
Blood cells
genetic disorders 10-9
C
Calcitonin
as a cancer marker 11-6
Calcium
endocrine regulation 7-6, 7-11
bioactive fraction 7-14
Calculated value
calculation 1-4
Calibration
calibrators 2-2
constructing a calibration curve 2-2
evaluating a calibration curve 2-17
regression analysis 2-3
Cancer
cancer cells 11-2
diagnosis 11-14
local effects 11-2
genetic abnormalities 11-2, 11-15
marker substances 11-4
monitoring
assessing therapy 11-17
tumor recurrence 11-18
prediction
predictive factors 11-16
quantification 11-16
prognosis
prognostic factors 11-15
quantification 11-16
staging systems 11-15
screening for cancer 11-7
screening for a predisposition to cancer 11-12
systemic effects 11-1
Carcinoembryonic antigen
as a cancer marker 11-6, 11-18
Carrier detection
genetic disease 10-12
Cellular injury
see
Injury
Childhood and adolescence
as source of variability 6-7
Chromosome
abnormalities 10-1
fluorescence
in situ
hybridization 10-2
G-banding 10-1
Classification correlation
definition 3-6
in repeat testing 3-6
Clearance rate
as determinant of substance half-life 7-1
as determinant of substance plasma concentration
with absorption rate 7-5
with synthetic rate 7-1
clearance of exogenous substances 7-3
definition 7-1
drugs
see
drug clearance
organ clearance rate 7-2
Cobalamin
circulating forms 8-4
deficiency 8-5
Combination testing
diagnostic study performance 3-4
diagnostic plot 3-8
diagnostic ratio 3-7
discriminant function 3-7
multiphasic health screen 3-6
positivity rules 3-6
Complement
activation 9-7
Common units
conversion to SI units 1-4
definition 1-4
Confirmation of a diagnosis
threshold likelihood ratio for acceptance 3-13
Congenital adrenal hyperplasia
21-hydroxylase deficiency 10-7
newborn screening 10-11
Control material
use in internal quality control 2-9
Control rules
in internal quality control
detection of current quality degradation 2-9
detection of persistent quality degradation 2-11
multiple-rule procedure of Westgard 2-12
Creatine kinase
Index
3
