evaluating method quality 2-18
components 2-14
optimization of analytical variables 2-16
Method practicability
components 2-13
Method quality
analytical range 2-22
bias 2-4
definition 2-3
definitive method 2-6
evaluation 2-18
detection limit 2-6, 2-22
field method 2-6
imprecision 2-5, 2-20
measurement procedure 2-8
quality assurance program
external quality control 2-13
internal quality control 2-9
quality goals 2-6
reference method 2-6
resolving power 2-6
trueness 2-3, 2-18
Microbiology
see
Infectious agents
Minerals
see
Trace minerals
Minimum distinguishable difference
definition 2-6
evaluating 2-22
Model
active homeostatic regulation 7-6
drug disposition 12-1
endocrine homeostasis 7-8
markers of cancer 11-4
markers of infection 9-13
markers of tissue injury 9-1
metabolic fluxes 10-7
natural history of a disorder 5-2
trace minerals and vitamins 8-2
Molecular diagnostic studies
allele-specific oligonucleotide hybridization 10-5
definition 10-4
Northern blot hybridization 10-7
PCR (polymerase chain reaction) 10-4
PCR-based studies 10-4
polymorphism
diagnostic application 10-4
restriction fragment length polymorphism 10-5
Southern blot hybridization 10-5
Monitoring
markers of disease activity 5-7
markers of physiologic status
monitoring rules 5-7
time course following a status change 5-3
significant difference 5-4
markers of therapeutic response 5-8
Multiphasic health screen
diagnostic study performance 3-6
Mutations
carrier detection 10-12
definition 10-3
factor VIII deficiency
genetic disorders of blood cells 10-9
genetic disorders of metabolism 10-7
genetic disorders of plasma proteins 10-8
molecular diagnosis 10-4
prenatal detection 10-14
reproductive risk assessment 10-12
Myocardial infarction
cellular markers 9-2
N
Neutrophilia
in infection 9-13
Newborn period
as source of variability 6-7
Normal range
see
reference range
Northern blot hybridization
molecular diagnosis 10-7
Nutrients
classes of 8-1
O
Old age
as source of variability 6-7
Organ function
clearance rate 7-2
synthetic rate 7-2
Operating characteristic curve
in internal quality control 2-10
P
PCR (polymerase chain reaction)
description 10-4
PCR-based molecular diagnostic studies 10-4
Performance characteristic function
see
ROC curve
Plasma binding proteins
as determinant of bioactive fraction 7-13
disposition of trace minerals and vitamins 8-2
functions 7-11
table of 7-12
Plasma proteins
genetic disorders 10-8
drug binding 12-16
Polymorphisms
molecular diagnosis 10-6
of drug metabolizing enzymes 12-9
restriction fragment length polymorphism 10-5
Positivity rules
diagnostic ratio 3-7
Index
7
