as a marker of myocardial infarction 9-2
isoenzymes of 9-2
Creatinine clearance rate
calculation 6-4, 12-9
in adulthood and old age 6-4, 6-8
Creatinine physiology
in adulthood and old age 6-7
Cross-validation
in evaluation of classification studies 4-8
D
Definitive method
definition 2-6
Detection limit
definition 2-6
evaluating 2-22
Diagnostic-review bias
in evaluation of classification studies 4-2
Diagnostic study performance
combination testing 3-6
comparing diagnostic study performance 3-14
efficiency 3-4
likelihood ratio 3-9
multiphasic health screen 3-6
predictive value 3-4
prevalence 3-4
repeat testing 3-5
ROC curve 3-2
sensitivity 3-1
specificity 3-1
Diagnostic plot
positivity rule for combination testing 3-8
Diagnostic ratio
positivity rule for combination testing 3-7
Diagnostic window
definition 9-3
variable timing 9-3
Difference analysis
in method comparisons 2-26
Discriminant function
positivity rule for combination testing 3-7
Drug bioavailable fraction
definition 12-3
individualized 12-10
Drug clearance
definition 12-3
extraction fraction 12-3
individualized 12-8
nonlinear elimination kinetics 12-16
organ clearance 12-3
polymorphisms of metabolizing enzymes 12-9
Drug disposition
clearance 12-3
determining individual kinetic parameters 12-10
distribution 12-1
half-life 12-13
multiple dosing
individualized dosing 12-7
dosing interval 12-4, 12-7
loading dose 12-4, 12-7
maintenance dose 12-4, 12-7
plasma disposition curves 12-4
single dosing
plasma disposition curves 12-2
variability 12-5
Drug effect
effect site disposition curves 12-5
instantaneous and noninstantaneous 12-5
Drug elimination
see
drug clearance
Drug dosing
adjusting dose regimen
clinical monitoring 12-12
therapeutic drug monitoring 12-12
individualizing initial dose regimen 12-7
Drug half-life
definition 12-13
Drug molecular heterogeneity
active metabolites 12-15
chirality 12-15
plasma protein binding 12-16
Drug toxicity
Bayes’ formula 12-17
Drug volume of distribution
definition 12-1
individualized 12-8
E
Efficiency
definition 3-4, 3-17
Endocrine systems
evaluation of function 7-8
plasma protein binding of hormones 7-12
regulatory function 7-8
Erythrocyte sedimentation rate
as a measure of plasma fibrinogen concentration 9-6
definition 9-6
Essential nutrients
definition 8-1
table of 8-1
Exclusion of a diagnosis
threshold likelihood ratio for rejection 3-13
External quality control
definition 2-13
F
Factor VIII deficiency
carrier detection 10-13
mutations causing 10-14
Index
4
