age-based variability 6-6
classification and 1-6
definition 1-5
pharmacologic variability 12-5
race-based variability 6-5
sex-based variability 6-4
sources of 1-5
Internal quality control
control material 2-9
control rules 2-9
definition 2-9
test-sample based control 2-12
Intraindividual variability
age-based variability 6-6
biorhythms 6-8
definition 1-5
monitoring and 1-6
pharmacologic variability 12-6
pregnancy 6-5
Iron
circulating forms 8-4
deficiency 8-5
excess 8-8
Isoenzyme
definition 9-2
K
Karyotype
definition 10-2
spectral karyotyping 10-2
L
Laboratory error
how to recognize 1-6
Likelihood ratio
definition 3-9
in Bayes’ formula 3-10
threshold likelihood ratio for acceptance 3-13
threshold likelihood ratio for followup 3-13
threshold likelihood ratio for rejection 3-13
Likelihood ratio curve
constructing 3-10
in evaluation of classification studies 4-6
Load test
in evaluation of micronutrient deficiency 8-6
Logistic function
probabilistic diagnostic classification 3-11
probabilistic prognostic classification 3-18
M
Magnesium
bioactive fraction 7-14
Markers
cancer
cancer cells 11-2
plasma substances 11-4
cobalamin deficiency 8-5
folate deficiency 8-5
genetic disorder of metabolism 10-7
hepatitis, viral 9-16
immune complex-mediated injury 9-5
injury
diagnostic window 9-3
estimating magnitude 9-4
injury versus death 9-1
test panels 9-4
tissue specificity 9-2
iron
deficiency 8-5
excess 8-8
monitoring disease activity 5-7
monitoring physiologic change 5-3
monitoring therapeutic response 5-8
myocardial infarction 9-2
organ function
clearance rate 7-2
synthetic rate 7-2
post-transfusion hemolysis 9-12
screening for subclinical disease 5-1
significant change in value 5-4
trace minerals
body stores 8-3
deficiency 8-5
supply reserve 8-3
transplant rejection 9-10
vitamins
body stores 8-3
deficiency 8-5
supply reserve 8-3
Matrix effects
cross-reaction effects 2-4, 2-19
definition 2-4
interference effects 2-4, 2-19
Measurement
calibration curve 2-2
measurement curve 2-2
measurement procedure 2-8
steps 2-1
Meta-analysis
in evaluation of classification studies 4-9
Metabolism
genetic disorders 10-7
Method comparison
clinical equivalence 2-23, 2-27
components 2-23
difference analysis 2-26
regression analysis 2-24
Method evaluation
evaluating a calibration curve 2-17
Index
6
