response to therapy, the clinical importance of
alterations in the physiologic state, and the turn-
around time and expense of the monitoring studies.
REFERENCES
Crabtree BF, Ray SC, Schmidt PM, O'Connor PJ, and
Schmidt DD. 1990. The individual over time: Time
series applications in health care research. J Clin
Epidemiol 43:241.
Eddy DM. 1982. Timing of repeated monitoring tests.
Clinic Lab Med 2:851.
Harris EK. 1983. Reference values for change: an adden-
dum. Clin Chem 29:997.
Harris EK and Yasaka T. 1983. On the calculation of a
"reference change" for comparing two consecutive
measurements. Clin Chem 29:25.
Parvin CA. 1991. Estimating the performance character-
istics of quality-control procedures when error persists
until detection. Clin Chem 37:1720.
Piccoli A, Rizzoni G, Tessarin C, Calconi G, Flilippini
M, Dugo M, and Borsatti A. 1987. Long-term
monitoring of renal transplant patients by a CUSUM
test on serum creatinine. Nephron 47:87.
Queraltó JM, Boyd JC, and Harris EK. 1993. On the
calculation of reference change values, with examples
from a long-term study. lin Chem 39:1398.
Skates SJ and Singer DE. 1991. Quantifying the potential
benefit of CA 125 screening for ovarian cancer. J Clin
Epidemiol 44:365.
Winkel P, Bentzon MW, Statland BE, Mouridsen H, and
Sheike O. 1982. Predicting recurrence in patients with
breast cancer based on cumulative laboratory results.
A new technique for the application of time series
analysis. Clin Chem 28:2057.
Monitoring
5-9